Volume 7, Number 1, March 2017
|Number of page(s)||8|
|Published online||03 March 2017|
Association of inflammatory cytokines with mortality in peritoneal dialysis patients
Graduate Institute of Clinical Medical Science, China Medical University College of Medicine, Taichung
2 Department of Internal Medicine, China Medical University College of Medicine, Taichung 404, Taiwan
3 Division of Nephrology, China Medical University Hospital, Taichung 404, Taiwan
4 Division of Nephrology, Taichung Veteran General Hospital, Taichung 407, Taiwan
5 Department of Medical Research, China Medical University Hospital, Taichung 404, Taiwan
6 Division of Immunology and Rheumatology, China Medical University Hospital, Taichung 404, Taiwan
7 Graduate Institute of Integrated Medicine, China Medical University, Taichung 404, Taiwan
* Corresponding author. No. 2, Yu-Der Road, Division of Nephrology, China Medical University Hospital, Taichung 404, Taiwan. E-mail address: email@example.com (S.-Y. Lin)
Accepted: 29 September 2016
Aims: Previous study on association between pro-inflammatory cytokines and mortality in PD population is limited. We aimed to investigate here.
Methods: Total 50 patients who underwent incident PD were enrolled in this study. We measured the titers of pro-inflammatory cytokines Interleukin-18(IL-18), Interleukin-6 (IL-6), and Interleukin-1ß (IL-1ß). Study outcomes were all-cause mortality, cardiovascular-related mortality, and infection-caused mortality. Cox-regression model was used.
Results: In this 7 year prospective study, IL-18 ≥ 804.3pg/ml, IL-6 ≥ 3.92 pg/ml, IL-1ß ≥ 0.86pg/ml, age ≥ 50 years-old, and existence of diabetes could be used as individual significant predictors for mortality in PD patients. Higher titers of IL-6 were associated with lower averaging albumin levels within 1st year of PD. Increasing numbers of these risk markers of mortality was associated with decreasing survival advantages (P = 0.001).
Conclusion: Age ≥ 50 years-old, diabetes, and inflammatory cytokines profiles at the start of PD therapy could predict for 7-year mortality in PD population.
Key words: Proinflammatory cytokines / Peritoneal dialysis / Mortality
© Author(s) 2017. This article is published with open access by China Medical University
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