Issue |
BioMedicine
Volume 7, Number 1, March 2017
|
|
---|---|---|
Article Number | 1 | |
Number of page(s) | 8 | |
DOI | https://doi.org/10.1051/bmdcn/2017070101 | |
Published online | 03 March 2017 |
Original article
Association of inflammatory cytokines with mortality in peritoneal dialysis patients
1
Graduate Institute of Clinical Medical Science, China Medical University College of Medicine, Taichung
404, Taiwan
2
Department of Internal Medicine, China Medical University College of Medicine, Taichung
404, Taiwan
3
Division of Nephrology, China Medical University Hospital, Taichung
404, Taiwan
4
Division of Nephrology, Taichung Veteran General Hospital, Taichung
407, Taiwan
5
Department of Medical Research, China Medical University Hospital, Taichung
404, Taiwan
6
Division of Immunology and Rheumatology, China Medical University Hospital, Taichung
404, Taiwan
7
Graduate Institute of Integrated Medicine, China Medical University, Taichung
404, Taiwan
* Corresponding author. No. 2, Yu-Der Road, Division of Nephrology, China Medical University Hospital, Taichung 404, Taiwan. E-mail address: oasisbestonly@yahoo.com.tw (S.-Y. Lin)
Received:
12
September
2016
Accepted:
29
September
2016
Aims: Previous study on association between pro-inflammatory cytokines and mortality in PD population is limited. We aimed to investigate here.
Methods: Total 50 patients who underwent incident PD were enrolled in this study. We measured the titers of pro-inflammatory cytokines Interleukin-18(IL-18), Interleukin-6 (IL-6), and Interleukin-1ß (IL-1ß). Study outcomes were all-cause mortality, cardiovascular-related mortality, and infection-caused mortality. Cox-regression model was used.
Results: In this 7 year prospective study, IL-18 ≥ 804.3pg/ml, IL-6 ≥ 3.92 pg/ml, IL-1ß ≥ 0.86pg/ml, age ≥ 50 years-old, and existence of diabetes could be used as individual significant predictors for mortality in PD patients. Higher titers of IL-6 were associated with lower averaging albumin levels within 1st year of PD. Increasing numbers of these risk markers of mortality was associated with decreasing survival advantages (P = 0.001).
Conclusion: Age ≥ 50 years-old, diabetes, and inflammatory cytokines profiles at the start of PD therapy could predict for 7-year mortality in PD population.
Key words: Proinflammatory cytokines / Peritoneal dialysis / Mortality
© Author(s) 2017. This article is published with open access by China Medical University
Open Access This article is distributed under terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided original author(s) and source are credited.