Volume 7, Number 2, June 2017
|Number of page(s)||12|
|Published online||14 June 2017|
Autophagy and its link to type II diabetes mellitus
Department of Medical Research, China Medical University Hospital, China Medical University, Taichung
2 School of Pharmacy, China Medical University, Taichung 404, Taiwan
3 Department of Biological Science and Technology, China Medical University, Taichung 404, Taiwan
4 Genetics Center, Department of Medical Research, China Medical University Hospital, Taichung 404, Taiwan
5 School of Chinese Medicine, China Medical University, Taichung 404, Taiwan
6 Institute of Biomedical Sciences, National Sun Yat-sen University, Kaohsiung 804, Taiwan
7 Department of Medical Genetics, China Medical University Hospital, China Medical University, Taichung 404, Taiwan
* Corresponding author. Department of Medical Research, China Medical University Hospital, China Medical University, No. 2, Yuh-Der Road, Taichung 404, Taiwan, E-mail address: firstname.lastname@example.org (F.-J. Tsai).
Accepted: 2 May 2017
Autophagy, a double-edged sword for cell survival, is the research object on 2016 Nobel Prize in Physiology or Medicine. Autophagy is a molecular mechanism for maintaining cellular physiology and promoting survival. Defects in autophagy lead to the etiology of many diseases, including diabetes mellitus (DM), cancer, neurodegeneration, infection disease and aging. DM is a metabolic and chronic disorder and has a higher prevalence in the world as well as in Taiwan. The character of diabetes mellitus is hyperglycemia resulting from defects in insulin secretion, insulin action, or both. Type 2 diabetes mellitus (T2DM) is characterized by insulin resistance and failure of producing insulin on pancreatic beta cells. In T2DM, autophagy is not only providing nutrients to maintain cellular energy during fasting, but also removes damaged organelles, lipids and miss-folded proteins. In addition, autophagy plays an important role in pancreatic beta cell dysfunction and insulin resistance. In this review, we summarize the roles of autophagy in T2DM.
Key words: Autophagy / Type 2 diabetes mellitus (T2DM) / Pancreatic β-cells / Insulin resistance
© Author(s) 2017. This article is published with open access by China Medical University
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