Volume 7, Number 2, June 2017
|Number of page(s)||6|
|Published online||14 June 2017|
Potential phytoestrogen alternatives exert cardio-protective mechanisms via estrogen receptors
Graduate Institute of Basic Medical Science, China Medical University, Taichung
2 Department of Biological Science and Technology, China Medical University, Taichung 404, Taiwan
3 Laboratory of Exercise Biochemistry, Department of Sports Sciences, University of Taipei, Taipei 100, Taiwan
4 Department of Nursing, Meiho University, Pingtung 912, Taiwan
5 Department of Hospital and Health Care Administration, Chia Nan University of Pharmacy & Science, Tainan 717, Taiwan
6 Division of Cardiology, Department of Internal Medicine, Armed-Force, Taichung General Hospital, Taichung 411, Taiwan
7 Department of Biotechnology, Bharathiyar University, Coimbatore, Tamil Nadu 641046, India
8 School of Chinese Medicine, China Medical University, Taichung 404, Taiwan
9 Department of Health and Nutrition Biotechnology, Asia University, Taichung 413, Taiwan
* Graduate Institute of Basic Medical Science, China Medical University. No. 91, Hsueh-shih Rd, Taichung 000, Taiwan. E-mail address: firstname.lastname@example.org (C.-Y. Huang).
Accepted: 10 February 2017
The 17 beta-estradiol (E2) is a sex hormone that is most abundant and most active estrogen in premenopausal women. The importance of E2 in providing cardioprotection and reducing the occurrence of heart disease in women of reproductive age has been well recognized. There are three subtype of estrogen receptors (ERs), including ERα, ERβ and GPR30 have been identified and accumulating evidence reveal their roles on E2-mediated genomic and nongenomic pathway in cardiomyocytes against various cardiac insults. In this review, we focus on the estrogen and ERs mediated signaling pathways in cardiomyocytes that determines cardio-protection against various stresses and further discuss the clinical implication of ERs and phytoestrogens. Further we provide some insights on phytoeostrogens which may play as alternatives in estrogen replacement therapies.
Key words: 17 Beta-estradiol / Estrogen receptor-alpha / Estrogen receptor-beta / Phytoestrogens / Survival signalling / Apoptosis
© Author(s) 2017. This article is published with open access by China Medical University
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