Issue |
BioMedicine
Volume 8, Number 1, March 2018
|
|
---|---|---|
Article Number | 1 | |
Number of page(s) | 11 | |
DOI | https://doi.org/10.1051/bmdcn/2018080101 | |
Published online | 26 February 2018 |
Review article
The molecular mechanism of contrast-induced nephropathy (CIN) and its link to in vitro studies on iodinated contrast media (CM)
1
Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 404, Taiwan
2
School of Medicine, China Medical University, Taichung 404, Taiwan
3
Department of Biological Science and Technology, China Medical University, Taichung 404, Taiwan
4
Department of Medical Imaging, Chung Shan Medical University Hospital, Taichung 402, Taiwan
5
School of Medical Imaging and Radiological Sciences, Chung Shan Medical University, Taichung 402, Taiwan
6
School of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
7
Department of Pharmacy, Buddhist Tzu Chi General Hospital, Hualien 970, Taiwan
8
Division of Reconstructive and Plastic Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei 112, Taiwan
9
Chinese Medicinal Research and Development Center, China Medical University Hospital, China Medical University, Taichung 404, Taiwan
10
School of Pharmacy, China Medical University, Taichung 404, Taiwan
11
Department of Diagnostic Radiology, Shin-Kong Wu Ho-Su Memorial Hospital, Taipei 111, Taiwan
12
School of Medicine, Fu-Jen Catholic University, Taipei 242, Taiwan
13
Department of Medical Imaging, Chia-Yi Christian Hospital, Chiayi 600, Taiwan
14
Genetics Center, Department of Medical Research, China Medical University Hospital, Taichung 404, Taiwan
15
School of Chinese Medicine, China Medical University, Taichung 404, Taiwan
16
Department of Medical Genetics, China Medical University Hospital, Taichung 404, Taiwan
* Corresponding author. Department of Medical Research, China Medical University Hospital, China Medical University, No. 2, YuhDer Road, Taichung 404, Taiwan. E-mail address: d0704@mail.cmuh.org.tw (F.-J. Tsai).
Received:
30
October
2017
Accepted:
7
November
2017
Iodinated contrast media (iodinated CM) have increased ability to absorb x-rays and to visualize structures that normally are impossible to observe in a radiological examination. The use of iodinated CM may destory renal function, commonly known as contrast-induced nephropathy (CIN), which can result in acute renal failure (ARF). This review article mainly focuses on the following areas: (1) classifications of iodinated CM: ionic or non-ionic, high-osmolarity contrast media (HOCM), low-osmolarity contrast media (LOCM) and iso-osmolarity contrast media (IOCM); (2) an introduction to the physical and chemical properties of the non-ionic iodinated CM; (3) the management of anaphylactic reaction by iodinated CM; (4) a suggested single injection of adult doses and maximum dose for non-ionic iodinated CM; (5) the molecular mechanism of contrast-induced nephropathy (CIN); (6) In vitro studies on iodinated CM. Based on above information, this review article provide an insight for understanding the drug safety of iodinated CM.
Key words: Iodinated contrast media / The management of anaphylactic reaction by iodinated contrast media / Dose for non-ionic contrast media / Contrast-induced nephropathy (CIN) / In vitro studies on iodinated contrast media
© Author(s) 2018. This article is published with open access by China Medical University
Open Access This article is distributed under terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided original author(s) and source are credited.