| Issue |
BioMedicine
Volume 8, Number 2, June 2018
|
|
|---|---|---|
| Article Number | 8 | |
| Number of page(s) | 6 | |
| DOI | https://doi.org/10.1051/bmdcn/2018080208 | |
| Published online | 28 May 2018 | |
Original article
A screening of growth inhibitory activity of Iranian medicinal plants on prostate cancer cell lines
1
Student Research Committee, Shahrekord University of Medical Sciences, Shahrekord, Iran
2
Medical Plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran
3
Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran
* Corresponding author. Department of Immunology, Shahrekord University of Medical Sciences, Rahmatiyeh, Shahrekord, Iran.
E-mail address: shirzad1951@yahoo.com
Received:
29
January
2018
Accepted:
12
March
2018
Background: Prostate cancer has been known as one of the most common malignancy in the men and it is therefore very important to prevent and treat this cancer. In this study, the anticancer effects of 20 species of medicinal plants in Iran, especially those grown in Chaharmahal and Bakhtiari province, were investigated on prostate cancer cell lines to identify potential natural alternatives for the development of prostate cancer anticancer drugs.
Methods: The plants were gathered from Chaharmahal va Bakhtyari and their aerial parts extracted through maceration method using ethanol 70%. Anti-proliferative activity of extracts on PC-3, DU145 and HDF cell lines was evaluated by MTT assay 48 hours after treatment.
Results: Euphorbia szovitsii Fisch. & C.A.Mey. and Achillea wilhelmsii had anti-proliferative activity more than other plants on PC-3. Also IC50s for Urtica dioica, Euphorbia szovitsii Fisch. & C.A.Mey. and Medicago sativa were lower amount among the examined plants on Du-145.
Conclusion: According to our result, Euphorbia szovitsii Fisch. & C.A.Mey., U. dioica and Medicago sativa with good anti-proliferative activity can serve as an effective source of natural products to develop new antiprostate cancer drugs.
Key words: Prostate cancer / Phytochemical compounds / Drug discovery / Antiproliferation
© Author(s) 2018. This article is published with open access by China Medical University
Open Access This article is distributed under terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided original author(s) and source are credited.