Volume 9, Number 4, December 2019
|Number of page(s)||6|
|Published online||21 November 2019|
Oral acute and sub-acute toxic effects of hydroalcoholic Terminalia chebula Retz and Achillea wilhelmsii extracts in BALB/c mice
Medical Plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran
2 Department of Pathology, School of Veterinary Medicine, Islamic Azad University, Shahrekord, Iran
* Corresponding author. Shahrekord University of Medical Sciences, Shahrekord, Iran. E-mail address: email@example.com (K. M. Naeini).
Accepted: 22 July 2019
Background: This study examined the acute and sub-acute toxic effects of Terminalia chebula and Achillea wilhelmsii extracts on the murine model.
Methods: In both phases, mice were assigned to intervention and control groups. At the end of study, the liver, kidney, and heart tissues were collected for histopathological studies.
Results: In the acute phase of the study, the safe dose was ≤5000 mg/kg for both extracts. In sub-acute phase, LD50 (95% CI) of Achillea wilhelmsii extract was determined ≥5000 mg/kg and that of Terminalia chebula extract 2754.436 (2438-3114) mg/kg. The highest dose of T. chebula extract induced few histopathological changes.
Conclusion: It will be useful to gain information on the minimum lethal doses of T. chebula and A. wilhelmsii to adopt safe doses of the two plants.
Key words: Achillea wilhelmsii / Acute toxicity / Animal Model / Sub-acute toxicity / Terminalia chebula
© Author(s) 2019. This article is published with open access by China Medical University
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