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Table 2

Resistance phenotype of class 1 integrons and their gene cassettes in76 intl1-positive Proteus mirabilis isolates.

Integrons group (no. of isolates) Amplicon size of integrons (Kb) Gene cassette(s) Resistance phenotype ERIC type (number)
A single amplicon produced
1 (1) 3.5 aadB-cat-oxa10-aadA1 KmCAmSmSp G (1)
2 (1) 3.2 aac(6’)-Ib-aacA7-cmlA GmCTpSmSp H (1)
3 (38) 2.1 dfr12-orfF-aadA2 TpSmSp C (9), D (4), E (2), G(21), H (1), ND(1)
4 (8) 1.8 aadB-aadA2 GmSmSp B (2), G (4), ND (2)
5 (5) 1.8 dfrA1-aadA1a TpSmSp A (1), B (1), G (3)
6 (3) 1.0 aadA1 SmSp E (1), G (2)
7 (5) 0.9 dfr12 Tp C (2), D (1), ND(2)
Two or more amplicons produced
8 (5) 2.1/0.9 dfr12-orfF-aadA2/dfr12 TpSmSp C (2), D (2), G (1)
9 (3) 2.1/1.8 dfr12-orfF-aadA2/aadB-aadA2 TpSmSp C (1), F (1), G(1)
10 (2) 2.1/1.8/0.9 dfr12-orfF-aadA2/aadB-aadA2/ dfr12 TpSmSpGm C (1), G (1)
11 (1) 3.1/2.1/1.8 aadB-cat-aadA1a/dfr12-orfF-aadA2/dfrA1- aadA1a KmTpSmSp G (1)
Negative for cassette regions
12 (4) 0.15 C (1), D (2), ND(1)

ND, not detected.

Am, ampicillin; C, chloramphenicol; Gm, gentamicin; Km, kenamycin; Tp, trimethoprim; Sm, streptomycin; Sp, spectinomycin.