Open Access

Table 7

The characteristics of individual reports investigating the genotypes of MMP1 promoter -1607 to gastric cancer risk.

Author Year Population Control, n Case, n Major findings
Mtsumura 2004 Japanese 166 215 MMP1 -1607 was not associated with GC risk, but may be markers for prognosis prediction such as lymph node metastasis and clinical stages.
Jin 2005 Mainland China 350 183 MMP1 -1607 was neither associated with GC risk nor prognostic indexes such as metastasis.
Fang 2010 Mainland China 252 246 There were no significant difference in the genotype or allele frequency of the MMP-1 16071G/2G between the case and control groups.
Devulapalli 2014 India 202 166 MMP1 -1607 was a determinant for GC risk, especially for those male gender, > 50 years, addicted to alcohol and smoking.
Dey 2014 India 145 145 MMP1 -1607 was not associated with GC risk. Other promoter SNPs on MMP1 may be markers for prognosis prediction such as metastasis.
Yang current Taiwanese 363 121 MMP1 -1607 was not associated with GC risk. It may interact with smoking and HP infection status determine the GC susceptibility.