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Table 2

The hepatic level of IL-6 (pg/mg protein), TNF-alpha (pg/mg protein), PGE2 (μg/mg protein), and COX-2 activity (nmol/min/mg protein) in normal (N) or diabetic mice (D) treated with RA at 0, low, or high dose for 9 weeks. Values are mean ± SD, n = 8. a-dmeans in a row without a common letter differ statistically, p < 0.05.

N D D + RA, low D + RA, high
IL-6 40 ± 5a 103 ± 9b 54 ± 8a 46 ± 4a
TNF-alpha 4.8 ± 0.6a 8.3 ± 1.0b 5.2 ± 0.3a 5.1 ± 0.5a
PGE2 6.4 ± 0.4a 19.5 ± 1.1c 14.4 ± 0.7b 12.9 ± 0.9b
COX-2 1.8 ± 0.2a 16.8 ± 0.8d 11.1 ± 1.0c 5.7 ± 0.6b