The hepatic level of IL-6 (pg/mg protein), TNF-alpha (pg/mg protein), PGE2 (μg/mg protein), and COX-2 activity (nmol/min/mg protein) in normal (N) or diabetic mice (D) treated with RA at 0, low, or high dose for 9 weeks. Values are mean ± SD, n = 8. a-dmeans in a row without a common letter differ statistically, p < 0.05.
|N||D||D + RA, low||D + RA, high|
|IL-6||40 ± 5a||103 ± 9b||54 ± 8a||46 ± 4a|
|TNF-alpha||4.8 ± 0.6a||8.3 ± 1.0b||5.2 ± 0.3a||5.1 ± 0.5a|
|PGE2||6.4 ± 0.4a||19.5 ± 1.1c||14.4 ± 0.7b||12.9 ± 0.9b|
|COX-2||1.8 ± 0.2a||16.8 ± 0.8d||11.1 ± 1.0c||5.7 ± 0.6b|
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