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Table 2

Odds ratio and 95% confidence interval of thiazolidinediones cancer by multivariable logistical regression model.

Crude Adjusted

Variable OR (95% CI) OR (95% CI)
Sex (male vs. female) 1.03 (0.99, 1.07)
Age (per one year) 1.00 (0.99, 1.003)
Thiazolidinediones use (never used as a reference) 0.99 (0.94, 1 .04) 0.94 (0.89, 0.99)
Other anti-diabetic drugs use (never used as a reference) 1.33 (1.26, 1.40) 1.35 (1.27, 1.42)
Comorbidities before index date (yes vs. no)
 Alcohol-related disease 1.16 (1.06, 1.26) 1.15 (1.06, 1.26)
 Cardiovascular disease 0.97 (0.93, 1.01)
 Chronic kidney disease 1.00 (0.95, 1.06)
 Chronic liver diseases 1.03 (0.98, 1.07)
 Chronic obstructive pulmonary disease 1.003 (0.96, 1.05)
 Colorectal adenoma 1.11 (0.96, 1.29)
 Hyperlipidemia 0.99 (0.96, 1.03)
 Hypertension 0.97 (0.93, 1.02)
 Inflammatory bowel disease 1.14 (0.98, 1.33)

Variables which were statistically associated with colorectal cancer in a univariable model were further included in a multivariable model. Only other anti-diabetic drugs and alcohol-related disease were included for adjustment.