Open Access

Table 1

The effects of paeoniflorin on the concentration of monoamines and their metabolites in the cerebral cortex of anesthetic rats with microdialysis.

pg/ml control
i.c.v. with paeoniflorin (100 mg)
20 min 40 min 60 min 20 min 40 min 60 min 80 min 100 min 120 min
EPI 2.25 0.93 1.56 1.03 1.58 1.46 0.85 1.06 0.77
±0.99 ±0.71 ±0.71 ±0.60 ±0.81 ±0.78 ±0.29 ±0.40 ±0.40
NE 15.30 9.00 8.41 8.67 7.62 6.66 6.94 5.46 6.75
±3.98 ±1.01 ±1.25 ±1.89 ±1.54 ±1.03 ±1.00 ±0.79 ±1.74
DA 0.71 0.58 0.81 0.73 0.55 0.81 0.65 0.55 0.44
±0.19 ±0.46 ±0.22 ±0.23 ±0.23 ±0.31 ±0.28 ±0.28 ±0.22
HVA 45.35 40.24 50.44 56.10 56.35 59.66 45.59 48.20 41.93
±7.67 ±7.41 ±9.58 ±12.02 ±13.98 ±16.68 ±10.62 ±7.56 ±5.41
DOPAC 44.18 42.52 54.05 56.31* 52.20* 54.87* 46.06 49.73 51.61
±10.21 ±8.65 ±8.89 ±8.43 ±11.03 ±11.55 ±9.38 ±9.65 ±10.05
5-HIAA 62.64 57.40 69.07 75.27* 82.35** 85.81* 78.39 80.82** 74.95*
±8.29 ±8.78 ±8.53 ±9.50 ±10.71 ±12.29 ±14.22 ±8.70 ±8.99

The concentration of 5-HT was not detectable.

Data are shown as mean ± S.E. (n = 8); * P < 0.05, ** P < 0.01 compared with control.