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Table 3

Effects of paeoniflorin (PF, 96 mg, i.c.v.) on the content of monoamines and their metabolites of the brain in mice.

ng/g tissue Cortex Striatum Medulla Spinal cord

control PF control PF control PF control PF
EPI 19.37 70.11 313.69 204.14 258.84 206.65 115.94 86.07
±7.45 ±24.59 ±106.31 ±46.31 ±74.32 ±52.40 ±31.63 ±13.12
NE 10.98 35.08* 84.62 196.02 44.13 117.36* 19.08 62.24
±6.69 ±3.53 ±29.43 ±46.06 ±28.04 ±41.71 ±12.31 ±39.77
DA 179.07 208.98 998.90 925.11 303.72 365.78 251.01 205.94
±28.87 ±32.40 ±364.74 ±170.53 ±29.29 ±56.70 ±57.93 ±60.21
5-HT 135.90 121.25 54.56 145.12 10.70 0.00*** -- --
±26.55 ±60.79 ±43.52 ±56.85 ±2.69 ±0.00
HVA 35.93 37.40 380.02 279.87 18.96 44.75 28.80 27.37
±5.79 ±5.52 ±80.74 ±72.70 ±1.00 ±27.82 ±25.24 ±17.66
DOPAC 61.00 147.50* 1627.05 1123.21 47.56 64.28 26.64 38.65
±8.52 ±31.37 ±231.95 ±153.50 ±7.76 ±7.60 ±10.92 ±7.46
5-HIAA 34.68 22.09 88.81 105.23 96.66 122.16 109.47 61.10
±6.57 ±10.23 ±35.05 ±36.03 ±24.86 ±11.26 ±52.68 ±14.34

Data are shown as mean ± S.E. (n = 8); * P < 0.05, *** P < 0.001 compared with control.