Open Access
Table 1
List of upregulated genes in the mRNA degradation pathway following PPARα activation.
| Gene Id | Gene Name | Log2 Fold Change | P-value Adjusteda | KEGG BRIT(mRNA Degradation Factors) | Localization |
|---|---|---|---|---|---|
| 3’→5’ decay | |||||
| ENSG00000120699 | RRP43, EXOSC8 | 1.216 | 0.0003653 | Core exosome factor | Nucleus/Cytoplasm |
| ENSG00000075914 | RRP42, EXOSC7 | 1.028 | 0.0013357 | Core exosome factor | Nucleus/Cytoplasm |
| ENSG00000171311 | CSL4, EXOSC1 | 1.348 | 0.0003653 | Core exosome factor | Nucleus/Cytoplasm |
| ENSG00000112941 | TRF4, PAPD7 | 2.015 | 0.0003653 | TRAMP complex | Nucleus |
| ENSG00000039123 | Mtr4, SKIV2L2 | 1.727 | 0.0325274 | TRAMP complex | Nucleus |
| ENSG00000171824 | RRP6, EXOSC10 | 2.019 | 0.0003653 | Exosome cofactor | Nucleus/Cytoplasm |
| ENSG00000135698 | MPP6, MPHOSPH6 | 1.119 | 0.0075373 | Exosome cofactor | Nucleus |
| ENSG00000111596 | CNOT2, NOT2 | 2.235 | 0.0003653 | Ccr4-NOT complex | Cytoplasm |
| ENSG00000088038 | CNOT3, NOT3 | 1.839 | 0.0003653 | Ccr4-NOT complex | Cytoplasm |
| ENSG00000204351 | SKI2, SKIV2L | 1.773 | 0.0019390 | Ski complex | Cytoplasm |
| ENSG00000198677 | Ski3, TTC37 | 1.385 | 0.0003653 | Ski complex | Cytoplasm |
| 5’→3’ decay | |||||
| ENSG00000038358 | EDC4 | 1.443 | 0.0062746 | Decapping complex | Cytoplasm |
| ENSG00000114127 | XRN1, SEP1 | 2.397 | 0.0298322 | 5’ Exoribonuclease | Cytoplasm |