Open Access
Volume 7, Number 2, June 2017
Article Number 11
Number of page(s) 6
Published online 14 June 2017
  1. Pekka J, Erkki V, Jaakko T, Pekka P. Age, Cardiovascular risk factors, and coronary heart disease. Circulation. 1999, 99, 1165–1172. [CrossRef] [PubMed]
  2. Mosca L, Collins P, Herrington DM, Mendelsohn ME, Pasternak RC, Robertson RM, et al. American Heart Association. Hormone Replacement Therapy and Cardiovascular Disease. Circulation. 2001, 104 (4), 499–503. [CrossRef] [PubMed]
  3. Patten Richard D, Richard K. Estrogen replacement and cardiomyocyte protection. Trends Cardiovasc Med. 2006, 16, 69–75. [CrossRef] [PubMed]
  4. Rosano GM, Vitale C, Silvestri A, Fini M. Hormone replacement therapy and cardioprotection: the end of the tale?. Ann N Y Acad Sci. 2003, 997, 351–357. [CrossRef] [PubMed]
  5. Gustafsson JA.. Estrogen receptor β - a new dimension in estrogen mechanism of action. J Endocrinol. 1999, 163, 379–383. [CrossRef] [PubMed]
  6. Moras D, Gronemeyer H. The nuclear receptor ligand-binding domain: structure and function. Curr Opin Cell Biol. 1998, 384–391. [CrossRef] [PubMed]
  7. Heldring N, Pike A, Andersson S, Matthews J, Cheng G, Hartman J, et al. Estrogen receptors: how do they signal and what are their targets. Physiol Rev. 2007, 87, 905–931. [CrossRef] [PubMed]
  8. Schwabe JW, Neuhaus D, Rhodes D. Solution structure of the DNA- binding domain of the oestrogen receptor. Nature. 1990, 29, 45861.
  9. Chunyan Z, Karin D-W, Jan-A G. Estrogen receptor β: an overview and update. Nucl Recept Signal. 2008, 6, e003. [PubMed]
  10. Eric P, Jeffery A, Harriet S, Tudor O, Larry S, Helen H. Estrogen signaling through the transmembrane G protein-coupled receptor GPR30. Annu. Rev. Physiol. 2008, 70, 165–190. [CrossRef] [PubMed]
  11. Kim JK, Levin ER. Estrogen signaling in the cardiovascular system. Nucl Recept Signal. 2006, 4e013.
  12. Richard D, Isaac P, Mark J, Aronovitz Jason B, Flore C, et al. 17β-Estradiol reduces cardiomyocyte apoptosis in vivo and in vitro via activation of Phospho-inositide-3 kinase/Akt signaling. Circulation Research. 2004, 95, 692. [CrossRef] [PubMed]
  13. Lannigan DA. Estrogen receptor phosphorylation. Steroid. 2003, 68 (1), 1–9. [CrossRef]
  14. Eric P, Matthias B. Signaling, physiological functions and clinical relevance of the G protein-coupled estrogen receptor GPER. Prostaglandins other Lipid Mediat. 2009, 89, 89–97. [CrossRef]
  15. Bhupathy P, Haines CD, Leinwand LA. Influence of sex hormones and phytoestrogens on heart disease in men and women. Womens Health. 2010, 6, 77–95.
  16. Weng YS, Kuo WW, Lin YM, Kuo CH, Tzang BS, Tsai FJ, et al. Danshen mediates through estrogen receptors to activate Akt and inhibit apoptosis effect of Leu27IGF-II-induced IGF-II receptor signaling activation in cardiomyoblasts. Food Chem Toxicol. 2013, 56, 28–39. [CrossRef] [PubMed]
  17. Huang CY, Chen SY, Fu RH, Huang YC, Chen SY, Shyu WC, et al. Differentiation of embryonic stem cells into cardiomyocytes used to investigate the cardioprotective effect of salvianolic acid B through BNIP3 involved pathway. Cell Transplant. 2015.
  18. Henry LA, Witt DM. Resveratrol: phytoestrogen effects on reproductive physiology and behavior in female rats. Horm Behav. 2002 , 41, 220–228. [CrossRef] [PubMed]
  19. Lin CH, Lin CC, Ting WJ, Pai PY, Kuo CH, Ho TJ, et al. Resveratrol enhanced FOXO3 phosphorylation via synergetic activation of SIRT1 and PI3K/Akt signaling to improve the effects of exercise in elderly rat hearts. Age (Dordr) 2014, 36, 9705.
  20. Sheng R, Gu ZL, Xie ML, Zhou WX, Guo CY. EGCG inhibits cardiomyocyte apoptosis in pressure overload-induced cardiac hypertrophy and protects cardiomyocytes from oxidative stress in rats. Acta Pharmacol Sin. 2007, 28: 191–201. [CrossRef] [PubMed]
  21. Ou HC, Song TY, Yeh YC, Huang CY, Yang SF, Chiu TH, et al. EGCG protects against oxidized LDL-induced endothelial dysfunction by inhibiting LOX-1-mediated signaling. J Appl Physiol. 2010, 108: 1745–1756. [CrossRef] [PubMed]
  22. Guo Q, Zhao B, Li M, Shen S, Xin W. Studies on protective mechanisms of four components of green tea polyphenols against lipid peroxidation in synaptosomes. Biochim Biophys Acta. 1996 , 1304: 210–222. [CrossRef]
  23. Tang WJ, Hu CP, Chen MF, Deng PY, Li YJ. Epigallocatechin gal-late preserves endothelial function by reducing the endogenous nitric oxide synthase inhibitor level. Can J Physiol Pharmacol. 2006, 84: 163–171. [CrossRef] [PubMed]
  24. Ludwig A, Lorenz M, Grimbo N, Steinle F, Meiners S, Bartsch C, et al. The tea flavonoid epigallocatechin-3-gallate reduces cytokine- induced VCAM-1 expression and monocyte adhesion to endothelial cells. Biochem Biophys Res Commun. 2004, 316: 659–665. [CrossRef]
  25. Raetx CR, Whtifield C. Lipopolysaccharide endotoxins. Annu Rev Biochem. 2002, 71, 635–700. [CrossRef] [PubMed]
  26. Tavener SA, Kubes P. Is there a role for cardiomyocyte toll-like receptor 4 in endotoxemia?. Trends Cardiovasc Med. 2005 , 15, 153–157. [CrossRef] [PubMed]
  27. Liu CJ, Lo JF, Kuo CH, Chu CH, Chen LM, Tsai FJ, et al. Akt Mediates 17beta-estradiol and/or estrogen receptor alpha inhibition of LPS-induced tumor necrosis factor-alpha expression and myocardial cell apoptosis by suppressing the JNK1/2-NFkappaB pathway. J Cell Mol Med. 2009, 13 (9b), 3655–3667. [CrossRef] [PubMed]
  28. Theo P, Manfred N, Tertia J, Virginija J, Ludwig N. Estrogen effects in the myocardium: inhibition of NF-kB DNA binding by estrogen receptor-α and -β. Biochem Biophys Res Commun. 2001, 286 (5), 1153–1157. [CrossRef]
  29. Sun B, Xiao J, Sun XB, Wu Y. Notoginsenoside R1 attenuates cardiac dysfunction in endotoxemic mice: an insight into oestrogen receptor activation and PI3K/Akt signalling. Br J Pharmacol. 2013, 168 (7), 1758–1770. [CrossRef] [PubMed]
  30. Hao E, Lang F, Chen Y, Zhang H, Cong X, Shen X, et al. Resveratrol Alleviates Endotoxin-Induced Myocardial Toxicity via the Nrf2 Transcription Factor. PLoS One. 2013, 8 (7), e69452.
  31. Zhang T, Yan T, Du J, Wang S, Yang H.. Apigenin attenuates heart injury in lipopolysaccharide-induced endotoxemic model by suppressing sphingosine kinase 1/sphingosine 1-phosphate signaling pathway. Chem Biol Interact. 2014, S0009-2797 (14), 00406–2.
  32. Matori H, Umar S, Nadadur RD, Sharma S, Partow-Navid R, Afkhami M, et al. Genistein, a soy phytoestrogen, reverses severe pulmonary hypertension and prevents right heart failure in rats. Hypertension. 2012; 60 (2), 425–430.
  33. Heineke J, Molkentin JD. Regulation of cardiac hypertrophy by intracellular signaling pathways. Nat Rev Mol Cell Biol. 2006, 7 (8), 589–600. [CrossRef] [PubMed]
  34. Crowley SD, Gurley SB, Herrera MJ, Ruiz P, Griffith R, Kumar AP, et al. Angiotensin II causes hypertension and cardiac hypertrophy through its receptors in the kidney. Proc Natl Acad Sci. 2006, 3 (47), 17985–17990. [CrossRef]
  35. Barry SP, Davidson SM, Townsend PA. Molecular regulation of cardiac hypertrophy. Int J Biochem Cell Biol. 2008, 40(10), 2023–2039. [CrossRef] [PubMed]
  36. Freund C, Schmidt-Ullrich R, Baurand A, Dunger S, Scheider W, Loser P, et al. Requirement of nuclear factor-kappaB in angiotensin II-and isoproterenol-induced cardiac hypertrophy in vivo. Circulation. 2005, 111 (18, 2319–2325. [CrossRef] [PubMed]
  37. Beate F, Suzanne L, Albert S, Stephan L, Burkert P, Frank S, et al. Inhibition of calcineurin-NFAT hypertrophy signaling by cGMP-dependent protein kinase type I in cardiac myocytes. Proc Natl Acad Sci. 2002, 99 (17), 11363–11368. [CrossRef]
  38. Donaldson C, Eder S, Barker C, Aronovitz MJ, Weiss AD, Hall-Porter M, et al. Estrogen attenuates left ventricular and cardiomyocyte hypertrophy by an estrogen receptor-dependent pathway that increases calcineurin degradation. Circ Res. 2009 , 104 (2), 265–275. [CrossRef]
  39. Beate F, Suzanne L, Albert S, Stephan L, Burkert P, Frank S, et al. Inhibition of calcineurin-NFAT hypertrophy signaling by cGMP-dependent protein kinase type I in cardiac myocytes. Proc Natl Acad Sci. 2002, 99 (17), 11363–11368. [CrossRef]
  40. Filardo EJ, Quinn JA, Bland KI, FrackeltonJr. Estrogen-induced activation of Erk-1 and Erk-2 requires the G protein-coupled receptor homolog, GPR30, and occurs via trans-activation of the epidermal growth factor receptor through release of HB-EGF. Mol Endocrinol. 2000, 14 (10), 1649–1660. [CrossRef]
  41. Hu WS, Lin YM, Ho TJ, Chen RJ, Li YH, Tsai FJ, et al. Genistein suppresses the isoproterenol-treated H9c2 cardiomyoblast cell apoptosis associated with P-38, Erk1/2, JNK, and NFkB signaling protein activation. Am J Chin Med. 2013, 41 (5), 1125–1136. [CrossRef] [PubMed]
  42. Thorburn J, Thorburn A. The tyrosine kinase inhibitor, genistein, prevents alpha-adrenergic-induced cardiac muscle cell hypertrophy by inhibiting activation of the Ras-MAP kinase signaling pathway. Biochem Biophys Res Commun. 1994, 202 (3), 1586–1591. [CrossRef]
  43. Qin W, Du N, Zhang L, Wu X, Hu Y, Li X, et al. Genistein alleviates pressure overload-induced cardiac dysfunction and interstitial fibrosis in mice. Br J Pharmacol. 2014, [Epub ahead of print].
  44. Maulik SK, Prabhakar P, Dinda AK, Seth S. Genistein prevents isoproterenol-induced cardiac hypertrophy in rats. Can J Physiol Pharmacol 2012, 90 (8), 1117–1125. [CrossRef] [PubMed]
  45. World Health Organization Department of Health Statistics and Informatics in the Information, Evidence and Research Cluster.(2004). The global burden of disease 2004 update. Geneva: WHO.
  46. Antti S, Kari P, Markku K, Kenth H, Martti P, Liisa P. Apoptosis in human acute myocardial infarction. Circulation. 1997, 95, 320–323. [CrossRef] [PubMed]
  47. Yang S, Zheng R, Hu S, Ma Y, Choudhry MA, Messina JL, et al. Mechanism of cardiac depression after trauma-hemorrhage: increased cardiomyocyte IL-6 and effect of sex steroids on IL-6 regulation and cardiac function. Am J Physiol Heart Circ Physiol. 2004, 287 (5), 2183–2191. [CrossRef]
  48. Hayward CS, Kelly RP, Collins P. The roles of gender, the menopause and hormone replacement on cardiovascular function. Cardio-vasc Res. 2000, 46 (1), 28–49. [CrossRef]
  49. Yi Xu, Ivan A, Arenas Stephen A, Wayne P, Han Xu, et al. Estrogen improves cardiac recovery after ischemia/reperfusion by decreasing tumor necrosis factor α. Cardiovasc Res. 2006, 69, 836–844. [CrossRef]
  50. Weng YJ, Kuo WW, Kuo CH, Tung CH, Tung KC, Tsai CH, et al. BNIP3 induces IL6 and calcineurin/NFAT3 hypertrophic-related pathways in H9c2 cardiomyoblast cells. Mol Cell Biochem. 2010, 345, 241–247. [CrossRef]
  51. Vanden Hoek TL, Li C, Shao Z, Schumacker PT, Becker LB. Significant levels of oxidants are generated by isolated cardiomyocytes during ischemia prior to reperfusion. J Mol Cell Cardiol. 1997, 29 (9), 2571–2583. [CrossRef] [PubMed]
  52. Robin E, Guzy RD, Loor G, Iwase H, Waypa GB, Marks JD, et al. Oxidant stress during simulated ischemia primes cardiomyocytes for cell death during reperfusion. J Biol Chem. 2007, 282 (26), 1913343. [CrossRef]
  53. Liu H, Pedram A, Kim JK. Oestrogen prevents cardiomyocyte apoptosis by suppressing p38α-mediated activation of p53 and by down-regulating p53 inhibition on p38β. Cardiovas Res. 2011, 89 (1), 11928.
  54. Lin J, Steenbergen C, Murphy E, Sun J. Estrogen receptor-β activation results in S-nitrosylation of proteins involved in cardioprotection. Circulation 2009, 120 (3), 245–254. [CrossRef] [PubMed]
  55. Urata Y, Ihara Y, Murata H, Goto S, Koji T, Yudoi J, et al. 17Beta-estradiol protects against oxidative stress-induced cell death through the glutathione/glutaredoxin-dependent redox regulation of Akt in myocardiac H9c2 cells. J Biol Chem. 2006, 281 (19), 13092–02. [CrossRef] [PubMed]
  56. Weil BR, Manukan MC, Hermann JL, Wang Y, Abaranrll AM, Poynter JA, et al. Signaling via GPR30 protects the myocardium from ischemia/reperfusion injury. Surgery. 2010, 148 (2), 436–443. [PubMed]
  57. Zhai P, Eurell TE, Cotthaus RP, Jeffery EH, Bahr JM, Gross DR. Effects of dietary phytoestrogen on global myocardial ischemia-reperfusion injury in isolated female rat hearts. Am J Physiol Heart Circ Physiol. 2001, 281 (3), H1223–H1232. [CrossRef]
  58. Aneja R, Hake PW, Burroughs TJ, Denenberg AG, Wong HR, Zingarelli B. Epigallocatechin, a green tea polyphenol, attenuates myocardial ischemia reperfusion injury in rats. Mol Med. 2004, 10 (1-6), 55–62. [CrossRef] [PubMed]
  59. Deodato B, Altavilla D, Squadrito G, Campo GM, Arlotta M, Minutoli L, et al. Cardioprotection by the phytoestrogen genistein in experimental myocardial ischaemia-reperfusion injury. Br J Pharmacol. 1999, 128 (8), 1683–1690. [CrossRef] [PubMed]
  60. Ji ES, Yue H, Wu YM, He RR. Effects of phytoestrogen genistein on myocardial ischemia/reperfusion injury and apoptosis in rabbits. Acta Pharmacol Sin. 2004, 25 (3), 306–312. [PubMed]
  61. Takahashi K, Ouyang X, Komatsu K, Nakamura N, Hattori M, Baba A, et al. Sodium tanshinone IIA sulfonate derived from Danshen (Salvia miltiorrhiza) attenuates hypertrophy induced by angiotensin II in cultured neonatal rat cardiac cells. Biochem Pharmacol. 2002, 64 (4), 745–749. [CrossRef] [PubMed]
  62. Pradipta G, Nancy D, Stuart K. Mannose-6-phosphate receptors: new twist in the tale. Nat Rev Mol Cell Biol. 2003, 4 (3), 202–212. [CrossRef] [PubMed]
  63. Chang MH, Kuo WW, Chen RJ, Lu MC, Tsai FJ, Kuo WH, et al. IGF- II/mannose 6-phosphate receptor activation induces metalloproteinase-9 matrix activity and increases plasminogen activator expression in H9c2 cardiomyoblast cells. J Mol Endocrinol. 2008, 41 (2), 65–74. [CrossRef] [PubMed]
  64. Chu CH, Tzang BS, Chen LM, Kuo CH, Cheng YC, Chen YL, et al. IGF-II/mannose-6-phosphate receptor signaling induced cell hypertrophy and atrial natriuretic peptide/BNP expression via Galphaq interaction and protein kinase C-alpha/CaMKII activation in H9c2 cardiomyoblast cells. J Endocrinol. 2008, 197 (2), 381–390. [CrossRef] [PubMed]
  65. Chen RJ, Wu HC, Chang MH, Lai CH, Tien YC, Hwang JM, et al. Leu27IGF2 plays an opposite role to IGF1 to induce H9c2 cardio-myoblast cell apoptosis via Galphaq signaling. J Mol Endocrinol. 2009, 43 (6), 221–230. [CrossRef] [PubMed]
  66. Weng YS, Kuo WW, Lin YM, Kuo CH, Tzang BS, Tsai FJ, et al. Danshen mediates through estrogen receptors to activate Akt and inhibit apoptosis effect of Leu27IGF-II-induced IGF-II receptor signaling activation in cardiomyoblasts. Food Chem Toxicol. 2013, 56, 28–39. [CrossRef] [PubMed]

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